Buprenorphine molecule + transdermal matrix technology: 7 days of continuous buprenorphine delivery

Each Butrans patch provides your patients with 7 days of buprenorphine delivery

Steady-state plasma buprenorphine concentration levels were achieved by Day 3 during the first application

Butrans may be titrated after a minimum of 72 hours, based on the pharmacokinetic profile and time to reach steady-state levels

Mean buprenorphine plasma concentrations following 3 consecutives applicationh

After removal of Butrans, mean buprenorphine concentrations decrease approximately 50% within 10 to 24 hours, followed by a decline with an apparent terminal half-life of approximately 26 hours.

Patch diagram for illustrative purposes only. Not depicted in actual colors or scale

Buprenorphine is bound in an adhesive matrix and released gradually
When the Butrans patch is applied, buprenorphine diffuses into the skin and enters the systemic circulation
The amount of buprenorphine released from each system per hour is proportional to the active surface area

See how the Butrans patch should be applied and rotated on skin sites.

Dose
Conversion Tool

Calculate your patient’s initial Butrans dose.