Important Safety
Information and IndicationFull Prescribing
Information

Reassess the benefits, risks, and need for continued opioid therapy at each patient visit

Continue opioid therapy only if there is clinically meaningful improvement that outweighs risks to patient safety1

Consider how to discontinue opioid therapy if benefits do not outweight risksConsider how to discontinue opioid therapy if benefits do not outweight risks

If benefits do not outweigh harms of continued therapy, optimize other therapies and work with patients to lower the opioid dose or to taper and discontinue the opioid

See information about Butrans Titration and Cessation.
Opioid Analgesics REMS
Opioid Analgesics REMS

See information on Risk Evaluation and Mitigation Strategy.

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