Use the Dose Conversion Tool

Calculate the initial Butrans dose for your opioid-experienced patients

Before using the Dose Conversion Tool, please review this important information.

• This tool does not contain all of the important safety information needed to prescribe Butrans. Please refer to the Full Prescribing Information and the Dosing section for more information
• Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals
• Butrans is for transdermal use (on intact skin) only
• Each Butrans patch is intended to be worn for 7 days
• Butrans doses of 7.5, 10, 15, and 20 mcg/hour are for only for use in patients who are opioid experienced and in whom tolerance to an opioid of comparable potency has been established. Patients who are opioid-experienced are those receiving, for one week or longer, daily opioid doses up to 80 mg/day of oral morphine or an equianalgesic dose of another opioid
• Initiate the dosing regimen for each patient individually, taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience and risk factors for addiction, abuse, and misuse
• Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with Butrans and following dosage increases
• Butrans should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain
• Discontinue all other around-the-clock opioid drugs when Butrans therapy is initiated
• There is a potential for buprenorphine to precipitate withdrawal in patients who are already on opioids
• Instruct patients not to use Butrans if the pouch seal is broken or the patch is cut, damaged, or changed in any way and not to cut Butrans
• Instruct patients to avoid exposing Butrans to external heat sources, hot water, or prolonged direct sunlight